Table 2 Mixed model analysis of variance (ANOVA) results for all outcomes. All models included main effects of time-point (admission and discharge from outpatient pulmonary rehabilitation), sex, severiy of Covid-19 (outpatient vs. inpatien), as well as their interactions. Only significant interactions are listed, which were followed up by stratification of the sample by sex. For stratified cohorts, only sognificant effects are listed

6-Minute Walking Distance, % predicted

 Sex

n.s.

 Time-Point

1, 218

238.6

< 0.0001

 Covid-19

n.s.

1-Second Forced Expiratory Volume, % predicted

 Sex

n.s.

 Time-Point

1, 227

24.3

< 0.0001

 Covid-19

1, 228

4.6

0.032

 Sex * Time-Point

1, 227

3.9

0.051

 Sex * Covid-19

1, 227

6.9

0.009

Males

Time-Point

1, 106

16.2

0.001

Covid-19

1, 106

5.6

0.019

Females

Time-Point

1, 121

8.2

0.005

Maximal Inspiratory Pressure

 Sex

1, 225

12.1

0.0006

 Time-Point

1, 225

340.6

< 0.0001

 Covid-19

n.s.

 Sex * Time-Point

1, 225

5.9

0.0158

Males

Time-Point

1, 105

136.7

< 0.0001

Females

Time-Point

1, 120

204

< 0.0001

Diffusion Capacity of Carbon Monoxide, % predicted

 Sex

n.s.

 Time-Point

1, 181

16.2

0.0001

 Covid-19

1, 181

22.3

< 0.0001

Dyspnea (Medical Research Council Scale)

 Sex

1, 237

9.2

0.0027

 Time-Point

1, 237

160.1

< 0.0001

 Covid-19

1, 237

10.4

0.0014

 Sex * Covid-19

1, 237

2.9

0.0510

Males

Time Point

1, 113

65.2

< 0.0001

Females

Time Point

1, 124

96.7

< 0.0001

Covid-19

1, 132

11.0

0.0012

post-Covid Functional Status Scale

 Sex

1, 234

8.3

0.0043

 Time-Point

1, 234

295.8

< 0.0001

 Covid-19

n.s.